Total (n = 69) | Comparison as randomized (n = 42) | Comparison not as randomized (n = 27) | |
---|---|---|---|
Journal type | |||
Specialty | 56 (81%) | 30 (71%) | 26 (96%) |
General | 13 (19%) | 12 (29%) | 1 (4%) |
Funding source | |||
Solely industry | 14 (20%) | 9 (21%) | 5 (18.5%) |
Part industry | 17 (25%) | 12 (29%) | 5 (18.5%) |
Non-industry | 31 (45%) | 18 (43%) | 13 (48%) |
Unknown | 7 (10%) | 3 (7%) | 4 (15%) |
Trial registration | |||
Reported | 30 (43%) | 22 (52%) | 8 (30%) |
Not reported | 39 (57%) | 20 (48%) | 19 (70%) |
Trial protocol | |||
Reported | 27 (39%) | 17 (40%) | 10 (37%) |
Not reported | 42 (61%) | 25 (60%) | 17 (63%) |
Common disease specialties | |||
Cardiology | 35 (51%) | 16 (38%) | 19 (70%) |
Infectious diseases | 3 (4%) | 2 (5%) | 1 (4%) |
Rheumatology | 3 (4%) | 3 (7%) | 0 |
Neurology | 2 (3%) | 1 (2%) | 1 (4%) |
Surgery | 2 (3%) | 1 (2%) | 1 (4%) |
Type of intervention | |||
Drug | 35 (51%) | 21 (50%) | 14 (52%) |
Surgery/procedure | 22 (32%) | 16 (38%) | 6 (22%) |
Counseling/lifestyle | 11 (16%) | 5 (12%) | 6 (22%) |
Equipment | 1 (1%) | 0 | 1 (4%) |
Study centers | |||
Single | 1 (2%) | 0 | 1 (4%) |
Multiple | 56 (81%) | 35 (83%) | 21 (78%) |
Unclear | 12 (17%) | 7 (17%) | 5 (18%) |
Main focus of non-primary publication | |||
Subgroup analyses | 27 (39%) | 11 (26%) | 16 (60%) |
Secondary outcomes | 29 (42%) | 19 (45%) | 10 (37%) |
Extended follow-up | 13 (19%) | 12 (27%) | 1 (4%) |
Time period assessed | |||
Reported | 39 (57%) | 23 (55%) | 16 (59%) |
Not reported | 30 (43%) | 19 (45%) | 11 (41%) |
Number of study groups in non-primary publication | |||
2 | 55 (80%) | 33 (79%) | 22 (82%) |
3 | 10 (14%) | 8 (19%) | 2 (7%) |
4 | 3 (4%) | 1 (2%) | 2 (7%) |
≥5 | 1 (2%) | 0 | 1 (4%) |
Number of patients randomized in non-primary publication | |||
Median (IQR) | 1,003 (347 to 2,699) | 762 (256 to 2,659) | 1,348 (660 to 2,928) |
Range | 34 to 20,479 | ||
34 to 21,906 | 36 to 21,906 | ||
Non-primary publication analyzed all randomized participants | |||
Yes | 28 (40%) | 20 (48%) | 8 (30%) |
No | 33 (48%) | 17 (40%) | 16 (59%) |
Unclear | 8 (12%) | 5 (12%) | 3 (11%) |
Flow diagram reported | |||
Yes | 17 (25%) | 9 (21%) | 8 (30%) |
No | 52 (75%) | 33 (79%) | 19 (70%) |
Identified as non-primary publication in the abstracta | |||
Yes | 40 (59%) | 23 (56%) | 17 (63%) |
No | 28 (41%) | 18 (44%) | 10 (37%) |