I and D outcomes are OSa | I outcome is PFSb, D outcome is OSa | ||||||||
---|---|---|---|---|---|---|---|---|---|
Estimated H R D for trials reached final stage | Estimated H R D for trials reached final stage | ||||||||
α 1 c | δ 1 d | e 1 e | %Passf | Mean (centiles) | %Bias | e 1 e | %Passf | Mean (centiles) | %Bias |
b) RE04 – | H R D (95% bootstrap CI): 1.05(0.90–1.21) | ||||||||
0.50 | 1.00 | 118 | 62 | 0.96(0.86,1.07) | − 1 | 116 | 45 | 0.96(0.85,1.07) | − 1 |
0.40 | 0.97 | 153 | 45 | 0.97(0.85,1.06) | 0 | 152 | 48 | 0.95(0.85,1.07) | − 2 |
0.30 | 0.94 | 195 | 48 | 0.95(0.85,1.06) | − 2 | 194 | 67 | 0.96(0.86,1.07) | − 1 |
0.20 | 0.91 | 252 | 58 | 0.95(0.85,1.06) | − 2 | 250 | 88 | 0.97(0.86,1.08) | 0 |
0.10 | 0.89 | 342 | 56 | 0.95(0.85,1.05) | − 2 | 339 | 71 | 0.96(0.86,1.06) | − 1 |
b) RE04 – | H R D (95% bootstrap CI): 1.05(0.90–1.21) | ||||||||
0.50 | 1.00 | 118 | 66 | 1.02(0.89,1.16) | - 3 | 116 | 67 | 1.03(0.89,1.19) | − 2 |
0.40 | 0.97 | 155 | 64 | 1.02(0.89,1.16) | - 3 | 152 | 33 | 1.01(0.88,1.16) | −4 |
0.30 | 0.95 | 199 | 29 | 0.98(0.87,1.10) | −7 | 196 | 21 | 0.99(0.87,1.13) | −6 |
0.20 | 0.93 | 259 | 16 | 0.95(0.85,1.04) | −10 | 255 | 27 | 0.99(0.87,1.13) | −6 |
0.10 | 0.91 | 355 | 21 | 0.97(0.86,1.08) | −8 | 351 | 3 | 0.94(0.80,1.07) | −10 |