Table 3 Sample size determination for endotoxin
Endotoxin baseline (U/L) | Difference in Δ-value (probiotics –placebo) | SD for change (common for both treatments) | Correlation for 1 and 2 measurements | Sample size (total) 2-tailed α: 0.05 Power: 80% | Sample size (total) 2-tailed α: 0.05 Power: 90% |
|---|---|---|---|---|---|
10 (± 6) | −2 | 5.34 | 0.60 | 224 | 298 |
|  | −2 | 5.04 | 0.65 | 200 | 266 |
|  | −2 | 4.68 | 0.70 | 176 | 236 |
|  | −2 | 4.26 | 0.75 | 148 | 198 |
|  | −2 | 3.78 | 0.80 | 116 | 154 |
|  | −2.5 | 5.34 | 0.60 | 144 | 192 |
|  | −2.5 | 5.04 | 0.65 | 128 | 172 |
|  | −2.5 | 4.68 | 0.70 | 114 | 152 |
|  | −2.5 | 4.26 | 0.75 | 96 | 128 |
|  | −2.5 | 3.78 | 0.80 | 76 | 100 |
|  | −3 | 5.34 | 0.60 | 100 | 134 |
|  | −3 | 5.04 | 0.65 | 90 | 120 |
|  | −3 | 4.68 | 0.70 | 80 | 106 |
|  | −3 | 4.26 | 0.75 | 68 | 90 |
|  | −3 | 3.78 | 0.80 | 54 | 70 |
|  | −4 | 5.34 | 0.60 | 58 | 76 |
|  | −4 | 5.04 | 0.65 | 52 | 68 |
|  | −4 | 4.68 | 0.70 | 46 | 62 |
|  | −4 | 4.26 | 0.75 | 40 | 52 |
|  | −4 | 3.78 | 0.80 | 32 | 40 |