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Table 1 Primary and secondary endpoints

From: Impact of different exercise training modalities on the coronary collateral circulation and plaque composition in patients with significant coronary artery disease (EXCITE trial): study protocol for a randomized controlled trial

Primary

Change in CBI after 4 weeks of treatment

Secondary

1. Change in plaque morphology by virtual

 

histology at 4 weeks as assessed by IVUS

 

2. Change in myocardial perfusion at 4 weeks and

 

12 months as assessed by adenosine MRI

 

3. MACE at 1, 3, 6 and 12 months

 

4. Hospitalization due to cardiovascular causes

 

5. Change in atherosclerotic parameters (hs-CRP,

 

ADMA, endostatin, EPC, ox LDL, cytokines,

 

adiponectine), lipid status and glucose status

 

6. Change in exercise capacity (ergospirometry) and

 

V02 peak