Screening | Month(s) | |||||
---|---|---|---|---|---|---|
0 | 3 | 6 | 12 | 24 | ||
Co-primary outcome measure | ||||||
MRI (cartilage volume changes) | ✓ | ✓ | ||||
WOMAC | ✓ | ✓ | ✓ | ✓ | ✓ | |
Secondary outcome measure | ||||||
MRI (other structural changes) | ✓ | ✓ | ||||
Lower limb muscle strength | ✓ | ✓ | ✓ | ✓ | ✓ | |
Other measures | ||||||
Core musculature measure | ✓ | ✓ | ✓ | |||
Hand grip strength | ✓ | ✓ | ✓ | ✓ | ✓ | |
Central and upper arm blood pressure | ✓ | ✓ | ✓ | ✓ | ||
Aortic stiffness | ✓ | ✓ | ✓ | ✓ | ||
Physical activity (IPAQ) | ✓ | ✓ | ||||
Body fat | ✓ | ✓ | ✓ | |||
Low foot pain | ✓ | ✓ | ✓ | ✓ | ✓ | |
Low back pain | ✓ | ✓ | ✓ | ✓ | ||
Depression | ✓ | ✓ | ✓ | ✓ | ✓ | |
Quality of life | ✓ | ✓ | ✓ | ✓ | ||
Previous knee injury and occupation | ✓ | ✓ | ||||
Weight | ✓ | ✓ | ✓ | ✓ | ✓ | |
Height | ✓ | ✓ | ||||
Girth measurements | ✓ | ✓ | ✓ | |||
Knee radiograph | ✓ | |||||
Serum 25-(OH)D | ✓ | ✓ | ✓ | |||
Serum calcium, phosphate, creatinine | ✓ | ✓ | ||||
Sun exposure | ✓ | ✓ | ✓ | ✓ | ||
Cigarette smoking | ✓ | ✓ | ||||
Diet (FFQ) and pedometer | ✓ | ✓ | ||||
Medications | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
Pill counts and adverse events | ✓ | ✓ | ✓ | ✓ | ✓ |