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Table 1 Coverage of topics and issues at monthly videoconferences for 2008-2010

From: Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group

Topic

Issues covered*

Issues in RCTs

• Biases resulting from patient withdrawal in RCTs and how to address them;

 

• Design and analysis issues in knowledge translation trials in primary care;

 

• Testing for blinding at the end of an RCT [5];

 

• Prognostic imbalance in RCTs;

 

• Dynamic allocation methods: why the controversy?

 

• Statistical issues in the use of composite outcomes clinical trials.

Issues in cluster RCTs

• Clustered measurement in cluster randomized trials;

 

• Imputation strategies for missing binary outcomes in cluster randomized trials.

Non-inferiority designs

• What's wrong with non-inferiority designs?

Pragmatic Trials

• A pragmatic-explanatory continuum summary (PRECIS) [6];

Meta-analysis issues

• Empirical priors for between-study heterogeneity in meta-analysis;

 

• Precision in meta-analysis;

 

• Indirect comparisons for evaluating healthcare interventions [7].

Other issues

• Bias in logistic regression due to omitted covariates;

 

• Statistical genetics and coronary artery disease;

 

• Longitudinal modeling when the response and time-dependent covariates are measured at distinct time-points.

  1. * Pdf Slides and audio versions of the presentations are available at http://www.cannectin.ca/default.cfm?id=25