Inclusion criteria | Exclusion criteria |
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• COPD GOLD stage II-III (i.e. FEV1/FVC <0.70 and FEV1 30-80% of predicted value). • Current cigarette smoking. • Willing to provide written informed consent. • Willing to refrain from smoking and avoid use of a bronchodilator >8 hours. • Registered in one of the recruitment institutes. | • COPD GOLD stage I or IV. • Active asthmatic component: present asthma by complaints, positive histamine provocation test, eosinofilia or reversibility ≥ 10% of predicted. • Unable to perform the whole experiment physically or due to communication problems. • Recent, active and relevant non-COPD respiratory disorders. |