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Table 2 Eligibility

From: A method to study the effect of bronchodilators on smoke retention in COPD patients: study protocol for a randomized controlled trial

Inclusion criteria

Exclusion criteria

• COPD GOLD stage II-III (i.e. FEV1/FVC <0.70 and FEV1 30-80% of predicted value).

• Current cigarette smoking.

• Willing to provide written informed consent.

• Willing to refrain from smoking and avoid use of a bronchodilator >8 hours.

• Registered in one of the recruitment institutes.

• COPD GOLD stage I or IV.

• Active asthmatic component: present asthma by complaints, positive histamine provocation test, eosinofilia or reversibility ≥ 10% of predicted.

• Unable to perform the whole experiment physically or due to communication problems.

• Recent, active and relevant non-COPD respiratory disorders.