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Table 1 Randomized controlled trials for the treatment of myocardial infarction in the acute setting using CMR parameters as a primary study endpoint (sorted by date of publication)

From: Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction

Primary CMR endpoint

Study

Treatment

Number of patients

Year published

Myocardial salvage index at days 2-4

Thiele et al. (LIPSIA-N-ACC study)[48]

High-dose N-acetylcysteine

251

2010

LV endsystolic volume index at 10-14 weeks

Abbate et al.[71]

Interleukin-1 blockade with anakinra

10

2010

LV ejection fraction at 6 months

Wöhrle et al.[72]

Autologous intracoronary bone-marrow cell therapy

42

2010

Myocardial salvage at 3 months

Lonborg et al.[47]

Ischemic postconditioning

118

2010

Infarct size at 4-6 months

Haeck et al.[73]

Proximal embolic protection and thrombus aspiration

206

2010

Infarct size and LV ejection fraction at 90 days

Patel et al. (APEX-AMI trial)[74]

Pexelizumab (anti-C5 complement antibody)

99

2010

LV endsystolic volume index at 24 weeks

Weir et al.[75]

Eplerenone

100

2009

LV ejection fraction at 6 months

Tendera et al. (REGENT study)[76]

Intracoronary infusion of bone-marrow derived selected CD34+CXCR4+ cells versus non-selected mononuclear cells

200

2009

Infarct size at 1 month

Song et al.[77]

Upstream high-dose tirofiban treatment

 

2009

LV ejection fraction at 4 and 12 months

Dill et al.[78]

Intracoronary administration of bone-marrow derived progenitor cells

54

2009

Infarct size after 5 days

Atar et al. (FIRE study)[79]

FX06

234

2009

Infarct size and microvascular obstruction at 2 days

Thiele et al.[25]

Intracoronary versus intravenous bolus abciximab application

144

2008

Infarct size at 3 days

Hahn et al.[80]

Distal protection device

39

2007

Global and regional myocardial function at 3 months

Engelmann et al.[81]

Granulocyte colony-stimulating factor

44

2006

LV ejection fraction at 6 months

Kang et al. (MAGIC Cell-3-DES trial)[82]

Intracoronary infusion of mobilized peripheral blood stem cells

96

2006

Systolic wall thickening at 6 months

Ripa et al. (STEMMI trial)[83]

Granulocyte colony-stimulating factor

78

2006

LV ejection fraction at 4 months

Janssens[84]

Transfer of autologous bone-marrow derived stem cells in the infarct-related artery

67

2006

Infarct size at 6 months

Thiele et al.[85]

Pre-hospital combination-fibrinolysis plus conventional care versus pre-hospital combination-fibrinolysis plus facilitated percutaneous coronary intervention

164

2005

LV ejection fraction at 6 months

Wollert et al. (BOOST trial)[86]

Intracoronary transfer of autologous bone-marrow cells

60

2004

LV volumes at 6 months

Darasz et al.[87]

Captopril and xamoterol

70

1995

  1. Abbreviations: CMR = cardiac magnetic resonance; LV = left ventricular.